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13,30 Also, CCL2 has long been described to improve osteoclastogenesis by inducing the expression of receptor activator of NF-κB (RANK) by osteoclast progenitors.31 RANK ligand (RANKL) further more promotes the differentiation of osteoclast progenitors into practical osteoclasts, which could aggravate DP by creating alveolar bone resorption.32 The